Correlation of Integral Hemodynamic Indices of Blood Flow in Personal-Specific Models of Carotid Bifurcation
УДК 519.6
Abstract
The paper studies the interdependence of integral hemodynamic indices characterizing the risk zones for atherosclerosis development in the carotid artery bifurcation region. Geometric models of vessels are constructed using the CT angiography data from patients to perform numerical calculations of steady-state periodic blood flow and hemodynamic indices related to parietal shear stress. Then, the regions with critical values of the indices higher than values for healthy arteries are mapped on the walls of the models using numerical calculations results. The integral values of the indices calculated over those regions are compared with similar values calculated using healthy vessels models and models constructed using data of endarterectomy patients. There is a strong linear correlation of the indices observed within a sample of101 models. The influence of critical values characterizing the critical region on the relationship of integral parameters is also investigated in the paper.
Downloads
Metrics
References
Ku D.N., Giddens D.P., Zarins C.K., Glagov S. Pulsatile Flow and Atherosclerosis in the Human Carotid Bifurcation. Positive Correlation Between Plaque Location and Low Oscillating Shear Stress // Arteriosclerosis. 1985. Vol. 5. No 3. P. 293–302. DOI: 10.1161/01.atv.5.3.293
Lee S.-W., Antiga L., Steinman D.A. Correlations Among Indicators of Disturbed Flow at the Normal Carotid Bifurcation // Journal of Biomechanics. 2009. Vol. 131. No 6. P. 1–7. DOI: 10.1115/1.3127252
Gallo D., Bijari P.B., Morbiducci U., et al. Segment-Cpecific Associations Between Local Haemodynamic and Imaging Markers of Early Atherosclerosis at the Carotid Artery: An In-Vivo Human Study // Journal of the Royal Society International. 2018. Vol. 15 (147). No 10. P. 1-11. DOI: 10.1098/ rsif.2018.0352
Lopes D., Puga H., Teixeira J., Lima R. Blood Flow Simulations in Patient-Specific Geometries of the Carotid Artery: A Systematic Review // Journal of Biomechanics. 2020. Vol. 111. No 10. P 1-15. DOI: 10.1016/j.jbiomech.2020.110019
Jung H., Kang T., Lee C-H., et al. Comparison of Haemo-dynamics in Carotid Endarterectomy: Primary Closure Versus Patch Angioplasty // Engineering Applications of Computational Fluid Mechanics. 2022. Vol. 16. No 1. P 1601-1618. DOI: 10.1080/19942060.2022.2102078
Harrison, G.J., How, T.V., Poole, et al. Closure Technique After Carotid Endarterectomy Influences Local Hemodynamics // Journal of Vascular Surgery. 2014. Vol. 60. No 2. P. 1-10. DOI: 10.1016/j.jvs.2014.01.069
Domanin M., Gallo D., Vergara C., et al. Prediction of Long Term Restenosis Risk After Surgery in the Carotid Bifurcation by Hemodynamic and Geometric Analysis // Ann Biomed Eng. 2019. Vol. 47. No 4. P. 1129-1140. DOI 10.1007/ s10439-019-02201-8
Tzirakis K., Kamarianakis Y., Kontopodis N., Ioannou C.V Classification of Blood Rheological Models Through an Idealized Symmetrical Bifurcation // Symmetry. 2023. Vol. 10. No 2. P. 1-17. DOI: 10.3390/sym15030630
Borisov VG., Zakharov Y.N., Vinogradov R.A., et al. Mathematical Modeling in Assessing the Risk of Restenosis After Carotid Endarterectomy // Biomedical Physics and Engineering Express. 2024. Vol. 10. No 3. P. 035011. DOI: 10.1088/2057-1976/ad30cb
Борисов В.Г., Захаров Ю.Н., Виноградов Р.А. и др. Численное исследование гемодинамических показателей в персонально-специфической модели сонной артерии // Известия Алтайского государственного университета. 2024. Т. 135. № 1 С. 82-88. DOI: 10.14258/izvasu(2024)1-11
Borisov V.G., Zakharov Y.N., Derbilova V.P., et al. The Influence of Inlet Flow Asymmetry on the Carotid Bifurcation Hemodynamics // Journal of Phy-sics: Conference Series. 2024. Vol. 2701. Р. 012010. DOI: 10.1088/17426596/2701/1/012010
Updegrove A., Wilson N.M., Merkow J., et al. Simvascular: An Open Source Pipeline for Cardiovascular Simulation // Annals of Biomedical Engineering. 2017. Vol. 45. No 3. P. 525-541. DOI: 10.1007/s10439 -016-1762-8
Copyright (c) 2025 Владимир Геральдович Борисов, Юрий Николаевич Захаров, Роман Александрович Виноградов, Виктория Павловна Дербилова, Элина Эльбрусовна Хетеева
This work is licensed under a Creative Commons Attribution 4.0 International License.
Izvestiya of Altai State University is a golden publisher, as we allow self-archiving, but most importantly we are fully transparent about your rights.
Authors may present and discuss their findings ahead of publication: at biological or scientific conferences, on preprint servers, in public databases, and in blogs, wikis, tweets, and other informal communication channels.
Izvestiya of Altai State University allows authors to deposit manuscripts (currently under review or those for intended submission to Izvestiya of Altai State University) in non-commercial, pre-print servers such as ArXiv.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY 4.0) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
