Measuring of Microcirculation Blood Flow in Capillaries with a Laser-Doppler Flowmetry
Abstract
The paper presents an approach for skin diseases diagnosis with a Laser-Doppler flowmetry evaluation of red blood cells flow changes in capillaries. The target parameter is the dynamic characteristic of blood microcirculation that is the blood flow change per unit time within a volume of interest. The noninvasive diagnostic system “LAKK-M” is utilized for study and comparative analysis of blood microcirculation index, standard deviation of blood flow range and coefficient of variation. Obtained results demonstrate statistical significance of blood microcirculation index measurements for healthy patients and patients suffering from psoriasis and dermatitis. Blood microcirculation index growth is related, firstly, to a vascular tone decrease that leads to increase of blood volume in capillaries. Secondly, index growth can be caused by blood congestion (bradyhemarrhea) that is accompanied by red blood cell concentration increase in the volume of interest due to microcirculation index is directly proportional to red blood cell number. The obtained data should be taken into consideration when developing new approaches for patient data processing and application of a Laser-Doppler flowmetry for early diagnosis of diseases.
DOI 10.14258/izvasu(2017)1-02
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