Modeling of Tumor Occurrence and Growth - I
УДК 517:612.6
Abstract
Cancer has recently overtaken heart disease as the world’s biggest killer. Cancer is initiated by gene mutations that result in local proliferation of abnormal cells and their migration to other parts of the human body, a process called metastasis. The metastasized cancer cells then interfere with the normal functions of the body, eventually leading to death. There are 200 types of cancer, classified by their point of origin. Most of them share some common features, but they also have their specific character. In this paper, we consider mathematical models of non-specific solid tumors in a tissue. The models incorporate the constitutive nature of the tissue, and the need for growing tumors to attract blood vessels. We also describe a general multiscale approach that involves cell cycle and incorporates non-specific genes mutation. Also, the trends and general features of modeling tumor growth are discussed. The main goal is set at revealing some trends and challenges on cancer modeling, especially related to the development of multiphase and multiscale models.
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References
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